Department of pathology, subharti medical college, nh58, delhi haridwar bypass, meerut, uttar pradesh, india. Late onset localized steatocystoma multiplex of the vulva. Androgenic stimulation of the sebaceous gland, along with environmental factors and the site and type of the keratin mutation, influence the onset of the sebaceous cysts. Steatocystoma simplex refers to a presence of a single cyst, which is usually acquired, and steatocystoma multiplex refers to a condition with multiple cysts, which is usually hereditary 1. Steatocystoma multiplex cause, treatment and diet for prevention steatocystoma multiplex options steatocystoma multiplex. Steatocystoma multiplex an overview sciencedirect topics. Aug 02, 2016 steatocystoma multiplex is a condition characterized by numerous skin cysts that tend to develop during puberty. The epidermoid cyst commonly known as the steatocystoma are within the skin slowly growing benign tumors of the retention cysts character filled with sebaceous and keratinous masses and containing elements of hair follicles. Steatocystoma multiplex, clinical picture 5891 steatocystoma multiplex, clinical picture 5892 steatocystoma multiplex, clinical picture 5893 steatocystoma multiplex, clinical picture 5894. Steatocystoma simplex histopathology differential diagnosis. Steatocystoma multiplex is a condition characterized by numerous skin cysts that tend to develop during puberty. Steatocystoma multiplex sm is a rare hamartomatous disorder of the pilosebaceous duct, manifesting clinically by multiple asymptomatic small dermal cysts.
Definitive diagnosis can be confirmed by histopathology. It is a disorder of the pilosebaceous unit characterised by the development of numerous sebumcontaining dermal cysts on the upper trunk, and other sites rich in sebaceous glands. Pathology of steatocystoma multiplex pathology, roy, map. Steatocystoma multiplex is a rare inherited disorder in which numerous cysts develop at puberty. This diagnosis was confirmed by histopathology that correlated with.
Despite histologic similarities, the true dermoid is not to be confused with steatocystoma. Steatocystoma multiplex is a distinct clinical entity whose nosologic status is secure. Steatocystoma multiplex is an inherited disease but cases can also occur where there is no family history of the. Steatocystoma multiplex is a benign condition that must be included in the differential diagnosis of eruptive vellus hair cysts, epidermal inclusion cysts, milia, trichilemmal cysts, and tumors of the follicular infundibulum. Similar appearance to compact keratin hyperkeratosis. Steatocystoma multiplex, a benign genetic skin disorder, can have a large developmental impact on an adolescent.
What is known is that it shows no prevalence based on gender or raceethnicity. Steatocystoma simplex is the solitary counterpart to steatocystoma multiplex. Natural cure for steatocystoma multiplex and alternative. Steatocystoma multiplex primary care dermatology society uk. Cutaneous keratocyst and steatocystoma unified as sebaceous. The histopathology of five resected steato cystoma multiplex nodules from three pa tients axillae showed typical steatocystoma multiplex with. Steatocystoma multiplex sm is one of the infrequent forms of keratin disorders characterized by multiple benign sebaceous gland papules andor nodules, usually located in haircovered areas where pilosebaceous glands are well developed. The cysts may become inflamed and cause scarring when they heal. Steatocystoma multiplex and adolescent development. Multiple vesicles and bullae on the scrotum photo quiz. Its presentation is often confused with acne, but it rarely responds to the latter conditions treatment. Our case is the oldest patient and the most late onset of steatocystoma multiplex reported in the literature. Steatocystoma multiplex is usually hereditary and it is inherited.
Pathology of steatocystoma multiplex dr sampurna roy md. May 01, 20 multiple vesicles and bullae on the scrotum. Steatocystoma multiplex mathews open access journals. The solitary cysts are identi cal to those of the typical syndrome. Jan 20, 2014 steatocystoma multiplex can be present at or shortly after birth, especially in familial cases, whereas sporadic forms of steatocystoma multiplex may present as late as 78 years.
Steatocystoma multiplex in nadiclinicseoul, korea steatocystoma multiplex. On histopathology, a cyst was noted in the middermis, lined by stratified. Mar 28, 2020 steatocystoma multiplex is a rare condition in which many small cysts filled with sebum appear on the skin. The differential diagnoses of steatocystoma and multiple epidermoid cysts were given and a biopsy was taken. Steatocystoma multiplex definition steatocystoma multiplex is a congenital inherited medical condition resulting to the presence of multiple cysts on the body usually on the chest but may also present in the upper arms or face. Steatocystoma multiplex in nadiclinicseoul, south korea steatocystoma multiplex. These growths begin in the skins sebaceous glands, which normally produce an oily substance called sebum that lubricates the skin and hair. Steatocystoma multiplex is located principally on the anterior chest, epigastrium, axillae, groin, neck area, and on the proximal part of the extremities 1, 3.
Mar 12, 2019 first described by jamieson in 1873, and coined by pringle in 1899, steatocystoma multiplex sm is an uncommon disorder of the pilosebaceous unit characterized by the development of numerous sebumcontaining dermal cysts. Steatocystoma multiplex is a skin disorder characterized by the development of multiple noncancerous benign cysts known as steatocystomas. Steatocystoma multiplex is a disorder of the pilosebaceous unit that occurs in either a sporadic or an autosomal dominant fashion. Steatocystoma multiplex involving the face and scalp. If a single cyst of this type is found, it is called steatocystoma simplex steatocystoma multiplex.
American society for clinical pathology academy of clinical. Steatocystoma multiplex jama dermatology jama network. Steatocystoma multiplex 387 cystoma are limited to the epidermis and its derived appendages. Jul 07, 2018 steatocystoma multiplex in nadiclinicseoul, south korea steatocystoma multiplex. Steatocystoma simplex is a skin condition characterized by a skin lesion that occurs with equal frequency in adult women and men, and is typically found on the face, trunk, or extremities 679. Steatocystoma multiplex, is a benign, autosomal dominant congenital condition resulting in multiple cysts on a persons body. Steatocystoma multiplex genetics home reference nih. Unlike the true dermoid, the tumors are always multiple, are. Suggestion for the treatment of steatocystoma multiplex. Multiple keratoacanthomas associated with steatocystoma. Steatocystoma multiplex is a unique disorder of the skin.
Steatocystoma multiplex is an uncommon benign disorder typically manifests as multiple asymptomatic intradermal cysts. Most of the cases of sm are sporadic and rarely inherited as an autosomal dominant trait, which is linked to a mutation in exon 1 of keratin 17 krt17 2, 3. Cysts most often develop on the chest, upper arms and face, but may develop all over the body in some cases. Small cyst with lining similar to corrugated cuticle of sebaceous duct, associated with sebaceous glands usually presents as multiple cysts steatocystoma multiplex, less commonly as solitary cyst steatocystoma simplex in adulthood. Lippincott journals subscribers, use your username or email along with your password to log in. Steatocystoma is a benign noncancerous skin cyst that arises from a sebaceous gland 1,2. Steatocystoma multiplex presenting as breast nodules. Steatocystoma multiplex is known as an acne conglobata and vulgaris lookalike. Steatocystoma multiplex cause, treatment and diet for. Histologically, it appears as an epitheliumlined cystic wall associated with sebaceous lobules. Steatocystoma multiplex and adolescent development a case report nancy m. Steatocystoma presents as a solitary lesion steatocystoma simplex or multiple lesions steatocystoma multiplex in adolescents or young adults. Steatocystoma multiplex is an uncommon skin condition first described by jamieson in 1873, and coined by pringle in 1899. Steatocystoma multiplex has been associated with ichthyosis and koilonychia, pachyonychia congenita, multiple hairs and acrokeratosis.
Steatocystoma multiplex, also known as sebocystomatosis or epidermal polycystic disease, is a disorder of the pilosebaceous unit characterised by multiple dermal cysts containing sebum. Cysts are hollow lumps, and sebum is an oily substance produced by the sebaceous glands that are found near hair roots. Keratoacanthomas have been associated with multiple carcinomas, discoid lupus erythematosus, and multiple sebaceous gland tumors with colonic and gastric carcinoma. A case of a steatocystoma multiplex limited to the scalp. These lesions arise sporadically or have an autosomal dominant pattern of inheritance. Pdf on apr 1, 20, manjula jain and others published acral. Pdf steatocystoma multiplex is an uncommon benign disorder typically manifests as multiple asymptomatic intradermal cysts.
Some cysts lack the typical histopathological features of steatocystoma multiplex. Steatocystoma multiplex is a rare benign disorder of the pilosebaceous unit. Steatocystoma multiplex is a benign skin disorder originating from the sebaceous and nevoid ducts. It is usually characterised by multiple, asymptomatic, skincoloured or yellowish, sebumcontaining dermal cysts.
Steatocystoma multiplex journal of postgraduate medicine. It can be sporadic, familial or a part of a syndrome. However, less frequently, steatocystoma multiplex involves the back, abdomen, and external genitalia. The content of a steatocystoma multiplex cystic lesion is sebum and therefore very different in nature from an acne lesion. Feature article steatocystoma multiplex and adolescent. Steatocystoma multiplex is a disorder that often follows an autosomal dominant pattern of inheritance and presents as multiple small cystic nodules predominantly on the chest, upper arms, axilla, and scrotum. If a single cyst of this type is found, it is called steatocystoma simplex. Steatocystoma multiplex university of miamis research profiles. The lesions have been described as hamartomatous malformations of the pilosebaceous duct junction hair follicle unit. Mutations in keratin 17 have been found in some cases.